Postdoc position in Protein modeling and Molecular dynamics simulations,Toulouse France (Deadline: 20.12.2025)

A post-doctoral position in structural biocomputing/molecular modelling available the IGBMC, Strasbourg and the TBI-INSA, Toulouse, France within the framework of an ANR-funded project.

The IGBMC is affiliated with INSERM, the CNRS and the University of Strasbourg. It carries out interdisciplinary research in structural, molecular and cellular biology: https://www.igbmc.fr/ The TBI is affiliated with INSA, the CNRS and INRAE, and carries out research in catalysis and enzyme engineering, systemic and synthetic biology, fermentation, process engineering and eco-design: https://www.toulouse-biotechnology-institute.fr/

Job description
The successful candidate will be a key member of the ANR-funded research project PyoClick that aims to investigate and design non-ribosomal peptide synthases (NRPS) involved in the bioproduction of new-to-nature peptides for biomedical applications.
The candidate wil be in charge of conducting molecular modelling studies to get a better understanding of molecular determinants involved in the function and substrate recognition of the targeted enzyme. The project will also aim at redesigning the enzyme to achieve the desired catalytic reaction and drive experimental construction of enzyme mutant libraries. This work will be carried out in close interaction with our experimental collaborators in charge of enzyme engineering and evaluation tasks.

The perspective post-doc will have the opportunity to work in a diverse and rich multidisciplinary environment, surrounded by both computational and experimental experts in the fields of enzyme catalysis, design and engineering.

The position is available starting from January 1st, 2026 and for a duration of 12 months (with possible renewal).

Applicants should send a detailed curriculum vitae, a letter of intent explaining their motivations for the position, and contact details of at least two references. Send your applications to:

Roland Stote: rstote@igbmc.fr Jérémy Esque: esque@insa-toulouse.fr